The HLA‐B14 Cross‐Reactive Group

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Abstract
The serological analysis of 24 HLA antisera, produced by pregnancy alone, containing B14 and up to 6 additional specificities was carried out on a selected lymphocyte panel of 316 cells. HLA typing was performed on the antiserum donors and 21 of their husbands. The results showed the following: bidirectional cross-reactivity between B8, B14.1, B14.2, B18 and Bw39; cross-reactivity between antibodies to these specificities and Bw22 (probably Bw22.1 (Cw3 associated) only); confirmation, with 5 antisera, of the cross-reactivity between anti-B14 and B5 (with evidence for the cross-reaction being with Bw51 and not Bw52); cross-reactivity between anti-Bw39 and B37; evidence for unidirectional cross-reactivitY between anti-Bw38 and B8, B14.1 and B14.2; preferential cross-reaction with the subdivisions of B14 (anti-B8 with B14.2 and anti-Bw39 with B14.1). The concept of shared antigenic determinants was briefly discussed in relation to these findings.