Bactericidal Synergistic Effect due to Chloramphenicol-induced Inhibition of Staphyloccal Penicillinase
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 23 (1) , 32-36
- https://doi.org/10.1159/000221968
Abstract
A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 of 20 .beta.-lactamase producing strains of Staphylococcus aureus. The synergism was due to chloramphenicol-induced inhibition of .beta.-lactamase production. With 7 of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonism.This publication has 2 references indexed in Scilit:
- CHLORAMPHENICOL-PROMOTED REPRESSION OF β-GALACTOSIDASE SYNTHESIS IN ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1963
- A NEW TECHNIQUE FOR THE STUDY OF THE BACTERICIDAL POWER OF ANTIBIOTIC ASSOCIATIONS DERIVED FROM TRANSFER ON CELLOPHANE - CROSS DISPOSITION1960