Tubular Reabsorption and Urinary Excretion of Acetoacetate and 3‐Hydroxybutyrate in Normal Subjects and Juvenile Diabetics

Publisher Website
Google Scholar
Abstract
The renal handling of acetoacetate (AA) and 3‐hydroxybutyrate (3‐HB) has been examined in 8 normal subjects and 7 insulin‐treated juvenile diabetics before and after i.v. infusion of sodium DL‐3‐hydroxybutyrate. In both normals and diabetics the ketone bodies were reabsorbed. At low filtration rates of AA and 3‐HB the reabsorption was nearly complete. With increasing filtration rate both the tubular reabsorption rate and the urinary excretion rate of AA and 3‐HB increased linearly. A maximal tubular reabsorption rate could not be demonstrated. In spite of higher filtration rates of AA and 3‐HB in the diabetics, the mean reabsorption percentage of either ketone body did not differ from that found in the normals.

This publication has 12 references indexed in Scilit: