2-Deoxyglycosyl Phosphorodithioates. A Novel Type of Glycosyl Donor. Efficient Synthesis of 2'-Deoxydisaccharides
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 10 (1) , 107-112
- https://doi.org/10.1080/07328309108543896
Abstract
The occurrence of 2'-deoxydisaccharides as structural units of a number of biologically important natural products explains the efforts involved in their synthesis.1 The majority of the reported procedures is based on addition reactions to glycals leading to 2-deoxyglycosyl donors which can be directly condensed with sugar aglycones yielding 2'-deoxydisaccharides or to glycosylating reagents with a “cryptodeoxy” function, which is removed under mild conditions after the formation of the glycosidic linkage. The main disadvantage of 2-deoxyglycosyl donors such as 2-deoxyglycosyl halides, is their chemical and configurational instability.Keywords
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