Polyclonal Nature of the IgM from Dysgammaglobulinemic Chickens
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 4 (6) , 529-536
- https://doi.org/10.3109/08820137509055791
Abstract
Chickens bursectomized at hatch and/or treated with anti-immunoglobulin reagents such as anti-μ, anti-μ and F(ab1)2anti-μu may become agammaglobulinemic, hypogammaglobulinemic, hypergammaglobulinemic or exhibit normal levels of immunoglobulins. IgM and IgY produced by these dysgammaglobulinemic chickens were demonstrated to be polyclonal in origin. The IgM from chickens with hyper-IgM-globulinemia is also polyclonal in origin unlike the situation seen in Waldenstrom's macroglobulinemia. These data do not rule out restricted allotype or subclass expression.This publication has 18 references indexed in Scilit:
- The Secretory Immunologic System of FowlInternational Archives of Allergy and Immunology, 1974
- Survival and function of bursa-derived cells in bursectomized chickensCellular Immunology, 1973
- Suppression of Chicken Immunoglobulin Ontogeny by F(ab′)2 Fragments of Anti-μ Chain and by Anti-L ChainInternational Archives of Allergy and Immunology, 1973
- Production of 19S IgM Antibodies with Restricted Heterogeneity from SharksProceedings of the National Academy of Sciences, 1971
- Suppression of Immunoglobulin G Synthesis as a Result of Antibody-Mediated Suppression of Immunoglobulin M Synthesis in ChickensProceedings of the National Academy of Sciences, 1970
- PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTIONThe Journal of Experimental Medicine, 1969
- Development and Function of the Immunoglobulin Producing SystemInternational Archives of Allergy and Immunology, 1969
- STEM-CELL MIGRATION IN DEVELOPING MYELOID AND LYMPHOID SYSTEMSThe Lancet, 1967
- Comparison of Polypeptide Chains of G-Globulin from Bursectomized and Normal Chickens.Experimental Biology and Medicine, 1967
- The Bursa of Fabricius and Antibody ProductionPoultry Science, 1956