Hemodynamics of Mephentermine in Man

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Abstract
THE clinical use of mephentermine¶ to elevate the arterial-blood pressure in man is presumably based upon the rationale that its pressor action is primarily due to an increase in myocardial contractility, with little effect upon the peripheral arteriolar resistance. This concept is mainly derived from animal studies.1 , 2 Recently, it was reported3 that this agent caused an increase in the height of the I-J wave as measured by the ballistocardiograph and an increase of the vascular resistance of the fingers as recorded by a segmental and digital plethysmograph. The inference was that mephentermine had both cardiac and peripheral action. There has . . .