Studies on Drug Nonequivalence. IX. Relationship between Polymorphism and Rectal Absorption of Indomethacin

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Abstract
Absorption of indomethacin from the rabbit rectum was examined in comparison with the suppositories containing indomethacin polymorphs (.alpha.- and .gamma.-form). Rectal suppositories were made with Witepsol H12. Plasma levels of .alpha.-form indomethacin was higher than that of .gamma.-form. The commercial product (Inteban suppository) made with polyethylene glycol (PEG) base was examined. Plasma level of Inteban was similar to that of .alpha.-form. The relationship between the thermodynamic activities of indomethacin polymorphs and their rectal absorption was discussed.