Human In vivo Radiation-Induced Biomarkers
- 15 September 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (18) , 6368-6371
- https://doi.org/10.1158/0008-5472.can-04-1883
Abstract
After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiments. Additional studies may reveal correlations between responses and either diagnosis or prognosis, and such in vivo validation marks an important step in the development of potentially informative radiation exposure biomarkers.Keywords
This publication has 13 references indexed in Scilit:
- Functional genomics of UV radiation responses in human cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
- Identifying biological themes within lists of genes with EASEGenome Biology, 2003
- Development and Assessment of a Quantitative Reverse Transcription-PCR Assay for Simultaneous Measurement of Four AmpliconsClinical Chemistry, 2003
- Ratio statistics of gene expression levels and applications to microarray data analysisBioinformatics, 2002
- Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetryInternational Journal of Radiation Biology, 2002
- Radiation Exposure Assessment using Cytological and Molecular BiomarkersRadiation Protection Dosimetry, 2001
- Biological indicators for the identification of ionizing radiation exposure in humansExpert Review of Molecular Diagnostics, 2001
- Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responsesOncogene, 1999
- Ratio-based decisions and the quantitative analysis of cDNA microarray imagesJournal of Biomedical Optics, 1997
- Use of a cDNA microarray to analyse gene expression patterns in human cancerNature Genetics, 1996