KINETICS OF TUMOR-CELL DEATH BY HYPERTHERMIC TREATMENT AND X-RAY-IRRADIATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (6) , 837-840
Abstract
Kinetics of cell death by hyperthermic treatment at 44.degree. C was analyzed using cultured mouse mammary carcinoma cells, and compared with that after X-irradiation. The cells treated with hyperthermia began to die randomly with a mean lethal time of 10 h after a lag time of 10 h. After irradiation, the lag time and mean lethal time were 40 and 34 h, respectively. Early appearance of dead cells by hyperthermic treatment indicates that the critical target is related to cellular metabolism.