Potentiating Effects of Materials of Plant and Animal Origin on Symptoms of Hypervitaminosis a in the Rat

Abstract
Immature rats were fed a purified ration containing a massive but relatively non-toxic dose of vitamin A. Supplements of alfalfa meal and other succulent plants resulted in a significant potentiation of the symptoms of hypervitaminosis A. Both the dried alfalfa juice and the water-washed pulp remaining after the extraction of the juice were active in this regard. Desiccated liver, yeast, a product derived from fermentation sources8 and aureomycin HCl also showed activity. In contrast to the above, supplements of all the known nutrients had little if any potentiating effect.