Pharmacodynamics of daily subcutaneous recombinant human interleukin-3 in normal volunteers*
- 13 January 1995
- journal article
- clinical trial
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 57 (1) , 32-41
- https://doi.org/10.1016/0009-9236(95)90263-5
Abstract
Normal volunteers received subcutaneous injections of recombinant human interleukin-3 (rhIL-3) on 4 consecutive days to characterize toxicity, pharmacokinetics, and hematopoietic effects. Dosages were 2.5, 5.0, and 7.5 micrograms/kg/day (n = 6 subjects per group). Adverse effects consisted predominantly of flu-like symptoms such as fever and headache. Mean area under the serum concentration-time curve and maximum serum concentration were linearly related to dose. Serum clearance was not apparently related to dose. Clearance increased slightly but significantly between days 1 and 4. Rapid but modest elevations in neutrophil and eosinophil counts were observed during treatment. Mean platelet counts rose modestly, peaking on day 10. Increases of CD34+ cell counts were correlated with increases of colony-forming unit-granulocyte macrophage (peak, day 7).Keywords
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