SIGNIFICANCE OF SERUM TUMOR-MARKERS IN PATIENTS WITH CARCINOMA OF THE OVARY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 63  (4) , 561-566
Abstract
A comparison of preoperative serum tumor markers (lactate dehydrogenase, lactate dehydrogenase isoenzymes, .alpha.-hydroxybutyrate dehydrogenase, alkaline phosphatase, aldolase, leucine aminopeptidase, cholinesterase, erythrocyte sedimentation reaction, carcinoembryonic antigen, .alpha.-fetoprotein, and .beta.2-microglobulin) was made in 76 patients with ovarian or uterine cancer. Patients (66) with benign ovarian tumor served as control subjects. From analysis of each tumor marker the greatest positive results were obtained with the markers .beta.2-microglobulin (57.1%), lactate dehydrogenase (53.1%), and hydroxybutyrate dehydrogenase (46.2%) for paients with carcinoma of the ovary. The use of these marker combinations in all ovarian cancer patients resulted in a marked increase of the positive rate from 57.1 to 85.2%. In stage I cases, the positive rate increased from 40.6 to 63.6%. [Diagnostic and therapeutic implications are considered.].