ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING
- 1 February 1995
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 46 (1) , 223-234
- https://doi.org/10.1146/annurev.med.46.1.223
Abstract
Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins, Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.Keywords
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