ADRENAL ESTROGENS. I. CONVERSION OF 4-C14-CORTISONE ACETATE TO 11-OXYGENATED ESTROGENS IN WOMEN
- 1 June 1961
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 21 (6) , 624-634
- https://doi.org/10.1210/jcem-21-6-624
Abstract
The bioconversion of adrenal corticosteroids to phenolic estrogens was investigated. After the administration of 4-C14-cortisone acetate to a castrated and adrenalectomized woman with breast cancer, 11β-hydroxyestrone and 11β-hydroxyestradiol were isolated from the urine. The radiochemical purity and identity of the C14-labeled conversion products were ascertained by paper chromatography, counter-current distribution, and carrier crystallization. After administration of 4-C14-cortisol to the. same patient, however, this conversion did not occur.Keywords
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