Effect of starvation on hyaluronic acid and extractable protein in skin of mice

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Abstract
When a sub-stantial loss of carcass nitrogen was induced in mice by starvation, there was a significant reduction of hyaluronic acid and chondroitin sulfate contents and also of extravascular albumin in the skin. The isolated hyaluronic acid from the starved animals exhibited a change in its characteristics so that when solutions containing albumin flowed through it, less albumin was retained and more passed through. The findings suggest that starvation results in loss in the skin and that this may be causally related to the simultaneous decrease of hyaluronic acid.[long dash]Authors.