Stabilization of Proteins Encapsulated in Cylindrical Poly(lactide-co-glycolide) Implants: Mechanism of Stabilization by Basic Additives
- 1 January 2000
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 17 (3) , 351-357
- https://doi.org/10.1023/a:1007513425337
Abstract
Purpose. A previous study from our group has shown that in theacidic microclimate of poly(lactide- co-glycolide) (PLGA) implants,encapsulated BSA forms insoluble noncovalent aggregates and...Keywords
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