Intrauterine herpes simplex infections

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Abstract
Cases (2) of intrauterine herpes simplex infections with congenital malformations are described. Common features included intrauterine growth retardation, microcephaly, encephalitis, chorioretinitis, psychomotor retardation and recurrent, grouped, cutaneous vesicles. Similar cases (7) with congenital malformations and cases of intrauterine herpes simplex infection without congenital malformations are reviewed. Intrauterine herpes simplex infections may be termed early when there is evidence of disturbed embryogenesis or late when congenital malformations are less specific or inapparent. The spectrum of intrauterine infections is similar to that of neonatally acquired infections.