Synergy between a non‐neuroleptic thioxanthene stereo‐isomer and penicillin in vivo
- 1 July 1988
- Vol. 96 (7-12) , 1079-1084
- https://doi.org/10.1111/j.1699-0463.1988.tb00984.x
Abstract
Some neuroleptic drugs of the phenothiazine and thioxanthene groups have an antimicrobial effect in vitro. This is also true for neuroleptically inactive stereo-isomeric analogs of the thioxanthenes e.g. trans(E)-clopenthixol (t-CPT). In a murine pneumococcus peritonitis model t-CPT demonstrated a slight, but non-significant antibacterial effect in doses of 0.3-0.9 mg per mouse, while higher doses seemed to enhance the bacterial virulence. If combined with subtherapeutic doses of penicillin, a significantly higher survival rate was obtained compared with either drug given alone. In vitro studies demonstrated a similar synergistic effect. These results indicate that at least one non-neuroleptic thioxanthene stereo-isomer has an antibiotic potential also in vivo. The mechanism of action is not known.Keywords
This publication has 19 references indexed in Scilit:
- Antibacterial Effect of Four PhenothiazinesBasic & Clinical Pharmacology & Toxicology, 1987
- THE ANTIBIOTIC EFFECT OF THE ANTI‐DEPRESSIVE DRUG FEMOXETINE AND ITS STEREO‐ISOMERIC ANALOGS ON DIARRHOEA PRODUCING ENTEROBACTERIACEAEActa Pathologica Microbiologica Scandinavica Series B: Microbiology, 1986
- Chiral pharmacology and its consequences for therapeutic monitoringClinical Biochemistry, 1986
- The Susceptibility of Plasmodium Falciparum in Vitro To Chlorpromazine and the Stereo‐isomeric Compounds Cis(z)‐ And Trans(E)‐ClopenthixolActa Pathologica Microbiologica Scandinavica Series B: Microbiology, 1985
- The Antibacterial Effect of Selected Neuroleptics on Vibrio CholeraeActa Pathologica Microbiologica Scandinavica Series B: Microbiology, 1985
- Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacologyEuropean Journal of Clinical Pharmacology, 1984
- Susceptibility of Bordetella species to growth inhibition and killing by chlorpromazineAntimicrobial Agents and Chemotherapy, 1983
- The Pneumococcus and the Mouse Protection Test: Importance of the Lag Phase in vivoChemotherapy, 1983
- Specific high-performance liquid chromatographic method for estimation of the cis(Z)- and trans(E)-isomers of clopenthixol and a N-dealkyl metaboliteJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Experiments to Illustrate The Effect Of Chlorpromazine On The Permeability Of The Bacterial Cell WallActa Pathologica Microbiologica Scandinavica Section B Microbiology, 1979