Cimetidine and ranitidine: Their interaction with human and pig liver microsomes and withpurified cytochrome P-450
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 9 (3) , 195-200
- https://doi.org/10.1007/bf03189641
Abstract
Cimetidine and ranitidine interact with microsomes from human and pig liver and with purified cytochrome P-450 in the ligand-type manner.The affinity for Cimetidine is about 10 times as high as that for ranitidine. Accordingly amplitudes of the specta are much higher for Cimetidine. These results are in accordance with those obtained earlier with rat liver microsomes. The inhibitory pot-ency of either compound with regard to dealkylation of 7-ethoxycoumarin appears to be less in the human preparation.This publication has 18 references indexed in Scilit:
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