Design of a water-soluble, solution-stable and biolabile prodrug of metronidazole for parenteral administration: N-substituted aminomethylbenzoate esters

This publication has 12 references indexed in Scilit:

• A novel solution-stable, water-soluble prodrug type for drugs containing a hydroxyl or an NH-acidic group
  Journal of Medicinal Chemistry, 1989
• Kinetics of regeneration of metronidazole from hemiesters of maleic acid, succinic acid and glutaric acid in aqueous buffer, human plasma and pig liver homogenate
  International Journal of Pharmaceutics, 1988
• Serum-Catalyzed Hydrolysis of Metronidazole Amino Acid Esters
  Journal of Pharmaceutical Sciences, 1985
• Strategies in the Design of Solution-Stable, Water-Soluble Prodrugs II: Properties of Micellar Prodrugs of Methylprednisolone
  Journal of Pharmaceutical Sciences, 1985
• Prodrugs as drug delivery systems XXVI. Preparation and enzymatic hydrolysis of various water-soluble amino acid esters of metronidazole
  International Journal of Pharmaceutics, 1984
• Prodrugs as drug delivery systems XXVII. Chemical stability and bioavailability of a water-soluble prodrug of metronidazole for parenteral administration
  International Journal of Pharmaceutics, 1984
• Leaching of hydrolytic enzymes from human skin in cutaneous permeation studies as determined with metronidazole and 5-fluorouracil pro-drugs
  International Journal of Pharmaceutics, 1983
• Metronidazole Phosphate—A Water-Soluble Prodrug for Parenteral Solutions of Metronidazole
  Journal of Pharmaceutical Sciences, 1982
• Intramolecular general base catalysis in the hydrolysis of 3-dimethylaminopropionates
  Journal of the Chemical Society, Perkin Transactions 2, 1976
• The Ionization Constant of Water and the Dissociation of Water in Potassium Chloride Solutions from Electromotive Forces of Cells without Liquid Junction¹
  Journal of the American Chemical Society, 1933