Temperature monitoring of focused ultrasound therapy by MRI
- 1 January 1994
- conference paper
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- Vol. 3, 1825-1828 vol.3
- https://doi.org/10.1109/ultsym.1994.401945
Abstract
The aim of the present study was to assess the feasibility of MRI monitoring the temperature distribution induced by focused ultrasound therapy of malignant tissue in vivo. Male Copenhagen rats bearing R3327-AT1 Dunning prostate tumors were sonicated in vivo with a self-constructed CW-ultrasound source. The sonication was performed in a conventional 1.5 T whole-body MR scanner. For MRI a T1-weighted saturation recovery TurboFLASH (SRTF) sequence (TR=10.2 ms, TE=4 ms, TI=300 ms, α=12°) with an acquisition time of 1.3 s per image was used. After sonication hypo-intense regions inside the tumors were monitored expanding centripetally off the focus by time. Tumor growth delay and postmortem histology correlated with the temperature distributions calculated from the SRTF signals. This will temperature to be controlled interactively during US hyperthermiaKeywords
This publication has 10 references indexed in Scilit:
- In vivo detection of ultrasonically induced cavitation by a fibre-optic techniqueUltrasound in Medicine & Biology, 1994
- MR temperature mapping of focused ultrasound surgeryMagnetic Resonance in Medicine, 1994
- Gene therapy for cancerTrends in Genetics, 1994
- Activation of photodynamic substances by high-energy ultrasound-a new therapeutic principle?Published by Institute of Electrical and Electronics Engineers (IEEE) ,1994
- Temperature mapping for high energy US-therapyPublished by Institute of Electrical and Electronics Engineers (IEEE) ,1994
- Characterization of extracorporeal ablation of normal and tumor-bearing liver tissue by high intensity focused ultrasoundUltrasound in Medicine & Biology, 1993
- MRI‐guided noninvasive ultrasound surgeryMedical Physics, 1993
- High intensity focused ultrasound for the treatment of rat tumoursPhysics in Medicine & Biology, 1991
- Progress in cancer management. Keynote addressCancer, 1983
- Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment of the primary lesionCancer, 1982