Lack of influence of the anabolic steroid nandrolondecanoate on bone metabolism

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Abstract
Eleven male patients with rheumatoid arthritis were treated with the anabolic steroid nandrolonedecanoate and parameters of Ca and bone metabolism were studied. No changes were found in the concentrations of Ca, P or hydroxyproline in serum and urine (corrected for the creaturia). A significant decrease (P < 0.01) was observed in the levels of alkaline phosphatase, but this was attributed to a change in liver enzymes, because the gamma glutamyl transpeptidase fell. Acid phosphatase levels showed an increase, possibly as a result of an effect of nandrolone decanoate on the prostate. No change was found during treatment in the serum levels of parathyroid hormone, calcitonin 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 25-dihydroxyvitamin D. A seasonal fluctuation was observed for 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D, but not for 1,25-dihydroxyvitamin D. Short-term treatment with the anabolic steroid nandrolone decanoate did not result in changes in parameters of Ca and bone metabolism.