T H 1 and T H 2 Cell Antigen Receptors in Experimental Leishmaniasis
- 5 March 1993
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 259 (5100) , 1457-1460
- https://doi.org/10.1126/science.8451641
Abstract
The complexity and chronicity of parasitic infections have obscured the identification of biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice infected with Leishmania major revealed the expansion of a restricted population of CD4+ cells. These cells expressed the V alpha 8-J alpha TA72, V beta 4 heterodimer in both progressive infection and protective immunity and across several major histocompatibility haplotypes. Thus, the same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals.Keywords
This publication has 35 references indexed in Scilit:
- The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.The Journal of Experimental Medicine, 1992
- Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis.The Journal of Experimental Medicine, 1992
- Regulation of Immunity to Parasites by T Cells and T Cell-Derived CytokinesAnnual Review of Immunology, 1992
- Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.The Journal of Experimental Medicine, 1992
- Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenicsNature, 1992
- Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy LesionsScience, 1991
- Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell ClonesScience, 1991
- Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.The Journal of Experimental Medicine, 1991
- Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.The Journal of Experimental Medicine, 1991
- Two monoclonal antibodies specific for the T cell receptor Vα8European Journal of Immunology, 1989