The effect of transmural field stimulation on the serotonin content in rat duodenal enterochromaffin cells-in vitro
- 1 September 1979
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 107 (1) , 83-87
- https://doi.org/10.1111/j.1748-1716.1979.tb06445.x
Abstract
The effect of transmural field stimulation (TFS)-in vitro-on the serotonin content in enterochromaffin cells (EC) in rat duodenum was studied by cytofluorimetry. TFS caused a significant 25% decrease of 5-HT in EC. The presence of tetrodotoxin or dl-propranolol in the stimulation bath antagonized the effect of TFS. In biopsies from rats pretreated with 6-OH-dopamine TFS had no effect on the 5-HT content in EC. The TFS induced decrease in 5-HT content may be due to a direct neural, probably .beta.-adrenoceptor mediated, influence on the EC.Keywords
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