THE EFFECT OF DEPANCREATIZATION AND LIGATION OF THE PANCREATIC DUCTS ON THE BLOOD AND LIVER LIPIDS OF DOGS

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Abstract
The accumulation of fat in the livers of depancreatized and of pancreatic-duct-ligated dogs is accompanied by a marked fall in blood plasma lipids. Little or no change occurs in the red blood cell lipids. The ratio of free to total plasma cholesterol rises above normal, but may recede to levels within normal limits. The normal range was established by analyses of 165 plasmas from 32 normal dogs; of the total cholesterol 24 to 34% (avg. 28.3 [plus or minus] S.D. 1.4%) was present as free cholesterol. Total cholesterol in normal dogs varied over the wide range of 67[long dash]358 mg. per 100 cc.

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