Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells
- 8 April 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 183 (1) , 107-110
- https://doi.org/10.1016/0014-5793(85)80964-9
Abstract
The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell.Phorbol esterCathecholamineProtein kinase CChromaffinSecretionCa2+-induced releasKeywords
This publication has 6 references indexed in Scilit:
- Effect of calmidazolium and phorbol ester on catecholamine secretion from adrenal chromaffin cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984
- The role of protein kinase C in cell surface signal transduction and tumour promotionNature, 1984
- Calcium control of exocytosis in bovine adrenal medullary cellsTrends in Neurosciences, 1984
- The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cellsFEBS Letters, 1983
- Phorbol diester receptor copurifies with protein kinase C.Proceedings of the National Academy of Sciences, 1983
- Calcium Chelation and BuffersPublished by Springer Nature ,1970