Fate of human corticotrophin immediately after intravenous administration to the rat

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Abstract
The distribution and degradation of tritium-labelled human 1–39 corticotrophin have been studied after intravenous administration to the rat. Within 5 min of injection a single major metabolite, 3–39 corticotrophin, appears in the circulation. This metabolite, however, has only 3·6% of the steroidogenic potency of 1–39 corticotrophin and the evidence suggests that it is formed in muscle and skin. By 5 min, extensive degradation had occurred in all the major tissues in the body (muscle, skin, liver, kidney, gut).