THE USE OF SILVER NITRATE AS A VITAL STAIN, AND ITS DISTRIBUTION IN SEVERAL MAMMALIAN TISSUES AS STUDIED WITH THE ELECTRON MICROSCOPE

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Abstract
After chronic administration of a dilute solution of silver nitrate in drinking water to rats, mice, and guinea pigs, granular deposits of metallic silver were detected in electron micrographs of the kidney, liver, thyroid, and pancreas. The silver deposits were in the form of extremely dense, angular particles with sharp outlines. They varied from aggregates a few microns in diameter down to granules at the limit of resolution of the electron microscope.