Modification by Cysteamine of Ultrasound Lethality to Chinese Hamster V-79 Cells

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Abstract
Exposure of Chinese hamster V-79 cells to 1.1 MHz continuous wave (CW) ultrasound at intensities of 10, 20 and 30 W/cm2 resulted in cell lysis and the loss of reproductive integrity (i.e., a decrease in plating efficiency) in the remaining intact cells. Sonication in the presence of 8 mM cysteamine, a free-radical scavenger, did not alter the amount of cell lysis, but did result in a smaller decrease in plating efficiency at 20 and 30 W/cm2. While free radicals do not appear responsible for ultrasonically induced cell lysis, they do appear at least partially responsible for loss of reproductive integrity in the remaining intact cells.

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