Enantiospecific synthesis of optically pure (S)-(+)-3-hydroxy-1-phenyl-1-butanone by bakers' yeast reduction
- 1 August 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 64 (8) , 1599-1601
- https://doi.org/10.1139/v86-265
Abstract
Bakers' yeast reduces 1-phenyl-1,3-butanedione with high chemo- and enantio-selectivity to give (S)-(+)-3-hydroxy-1-phenyl-1-butanone. The enantiomeric purity (> 98%) was determined by nmr analysis using a chiral shift reagent and the absolute configuration was determined by correlation with ethyl (S)-(+)-3-hydroxybutyrate.This publication has 3 references indexed in Scilit:
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