Vitamin E Intake Affects Serum Thromboxane and Tissue Essential Fatty Acid Composition in the Rat

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Abstract
The influence of dietary vitamin E on the composition of essential fatty acids in rat tissue and plasma lipids as well as serum thromboxane B2 was studied. Diets containing deficient (0mg/kg diet), adequate (100mg/kg) or supplemental (1,000 mg/kg) vitamin E were fed to young male rats for 10 weeks. The ratio of dihomo-γ-linolenic acid to arachidonic acid in phospholipids of plasma, liver, and testes was increased in vitamin-E-supplemented rats. Serum thromboxane B2 was increased in vitamin-E-deficient rats. The data support a role for vitamin E in affecting both metabolism of long chain fatty acids, i.e. dihomo-γ-linolenic acid, and conversion of arachidonic acid to thromboxane A2.