Characterization of Oxygen-Hemoglobin Equilibrium Curves Using Nonlinear Regression of the Hill Equation: Parameter Values for Normal Human Adults
- 1 January 1983
- book chapter
- Published by Springer Nature
- Vol. 159, 435-444
- https://doi.org/10.1007/978-1-4684-7790-0_37
Abstract
Measurements of oxygen concentration versus PO2 in blood from 33 normal adults were fitted, using a special nonlinear regression analysis, to the Hill equation to obtain the parameters describing the position (P50) and shape (n) of each oxygen-hemoglobin equilibrium curve (OHEC). Data between 20% and 97% saturation were described well by this empirical two-parameter model. The mean (+ SD) P50 and n were found to be 26.2 (+ 0.8) torr and 2.50 (+0.07), respectively, in good agreement with previously published values. Some normal individuals, however, deviated markedly from the averages indicating that the published values cannot be applied to everyone.Keywords
This publication has 10 references indexed in Scilit:
- Simple, accurate equations for human blood O2 dissociation computationsJournal of Applied Physiology, 1979
- Variability of oxygen affinity of normal blood: an automated method of measurementJournal of Applied Physiology, 1978
- A generalized approach to equilibrium modelsThe Journal of Physical Chemistry, 1977
- The Respiratory Functions of BloodPublished by Springer Nature ,1977
- Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of AllosteryNature, 1970
- An oxyhemoglobin dissociation analyzer.Journal of Applied Physiology, 1970
- Digital computer subroutine for the conversion of oxygen tension into saturation.Journal of Applied Physiology, 1966
- Blood gas calculator.Journal of Applied Physiology, 1966
- THE HEMOGLOBIN SYSTEMJournal of Biological Chemistry, 1925