DRUG-RESISTANCE AMONG SALMONELLAE IN KUWAIT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 35  (1) , 37-41
Abstract
The status of drug resistance among Salmonella spp. prevalent in Kuwait during 1979-1980 was assessed. Antibiotic sensitivity of 345 clinical isolates against 14 antimicrobial agents was done by disc-diffusion technique and their MIC was determined by plate dilution. Only 9.6% of these isolates were sensitive to all the 14 drugs. There was resistant to sulfisoxazole (78%), tetracycline (69%), kanamycin (61%), ampicillin (56%), streptomycin (53%), chloramphenicol (38%) and mezlocillin (38%). Multiple drug resistance (3 or more drugs) was seen in 71% of isolates and many of them were resistant to 5 or more drugs. The common resistance patterns observed were ACGKSSuT, ACKSSuT, ACSSuT and ASSuT. Cotrimoxazole was the drug of choice as only 15 strains (4%) were resistant to it. The minimum inhibitory concentration (MIC) of the resistant strains was invariably high. S. typhimurium was the most common (41%) single species and the frequency and level of resistance was higher in this serotype than in others.