INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BYd-CYCLOSERINE AND ITS SPECIFIC REVERSAL BYd-ALANINE

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Abstract
Moulder, JamesW. (University of Chicago, Chicago, Ill.),Dorothy L. Novosel, and Julius E. Officer. Inhibition of the growth of agents of the psittacosis group byd-cycloserine and its specific reversal byd-alanine. J. Bacteriol.85:707–711. 1963.—d-Cycloserine inhibited multiplication of four members of the psittacosis group in chick embryo yolk sac.d-Alanine reversed each inhibition. In infections with the agent of mouse pneumonitis, the most sensitive member of the psittacosis group tested,d-alanine competitively antagonized the growth inhibition produced byd-cycloserine. Of a number of other potential reversing agents, onlydl-alanyl-dl-alanine reversed the effect ofd-cycloserine on mouse pneumonitis agent. The significance of the susceptibility of the psittacosis group tod-cycloserine is discussed in light of the known mode of action of this antibiotic on bacteria.