Structural characterization of the urinary metabolites of iprindole in rat
- 1 January 1991
- journal article
- Published by Taylor & Francis in Xenobiotica
- Vol. 21 (10) , 1393-1405
- https://doi.org/10.3109/00498259109043214
Abstract
1. The in vivo metabolism of iprindole in rat is described. Each rat received a single dose of iprindole (10 mg/kg) and urine was collected for 48 h. 2. Fourteen metabolites of iprindole were isolated from rat urine after enzymic hydrolysis and their structures were determined by a computerized g.l.c.-mass spectrometric technique, before and after appropriate chemical derivatization. 3. Three concurrent metabolic pathways have been identified for iprindole in rat; aromatic ring hydroxylation is a minor pathway. 4. This is the first reported comprehensive study on the in vivo metabolism of iprindole in rat.Keywords
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