Isocitric dehydrogenase in the cerebrospinal fluid

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Abstract
The results of ICD [isocitric dehydro-genase] activity determinations in the CSF [cerebrospinal fluid] of 106 normal subjects and of 150 patients with various neurological disorders are reported. In the normal group, the results ranged from 0 to 12.2 units with a mean activity of 6.3 units. Marked increase of ICD activity was found in meningitis, where it correlated with the leukocyte count. Transient elevation was observed in 7 cases of cerebrovascular lesions. Only 1 out of 32 patients with multiple sclerosis showed elevated values. Pathological conditions studied included primary and secondary neoplasms of the central nervous system, viral and bacterial meningitis, cerebrovascular lesions, multiple sclerosis, and some other neurological diseases. As a diagnostic tool, ICD activity determination seems most promising in tumors of the central nervous system in this group, increase of ICD activity often precedes modifications in leukocyte count or in protein content of the CSF.

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