Factors affecting statistical power in the detection of genetic association
Open Access
- 1 June 2005
- journal article
- review article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 115 (6) , 1408-1418
- https://doi.org/10.1172/jci24756
Abstract
The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.Keywords
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