New adriamycin analogs. Synthesis and antitumor activity of 14-substituted 7-O-(3,4-di-O-acetyl-2,6-dideoxy-.ALPHA.-l-lyxo-hexopyranosyl)daunomycinones.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (8) , 1019-1025
- https://doi.org/10.7164/antibiotics.34.1019
Abstract
The 14-azido-, 14-thiocyanato-, 14-acetoxy- and 14-acetylthio- derivatives of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-.alpha.-L-lyxo-hexopyranosyl)daunomycinone were synthesized by displacement reactions conducted on the corresponding 14-bromide. The in vivo antitumor activities of the products were compared with that of the 14-hydroxyl derivative in the murine P-388 lymphocytic leukemia assay. The 14-acetoxy derivative was highly active and of low toxicity; the other products showed negligible or low activities.This publication has 3 references indexed in Scilit:
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