DEMONSTRATION OF THE PRESENCE DURING ACUTE INFLAMMATORY REACTIONS OF A SERUM FACTOR MITOGENIC FOR MACROPHAGES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 12  (2) , 147-159
Abstract
The existence of a mitogenic factor for macrophages in the serums of rats having undergone diverse immune and non-immune inflammatory reactions was investigated. Evolution of the mitogenic activity of inflammatory serums was studied over a 48-h period. The appearance of the mitogenic factor is very rapid since it can be found as early as 30 min after after injection of the irritant. In most cases the evolution of the mitogenic activity of serums reveals a biphasic aspect: a strong activity is observed 1 or 2 h after the injection of the irritant, followed by a decrease of this activity which becomes weak or even null towards the 6th h. It then increases to attain, after about 24 h, values almost equal to those seen for the 1st peak.