CHANGES IN GLUTAMIC ACID – OXALOACETIC ACID – TRANSAMINASE ACTIVITY IN THE LIVER AND KIDNEYS ON THE EFFECT OF HIGH DOSES OF PYRAMIDON (AMINOPYRINE)
- 1 July 1961
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 39 (7) , 1189-1191
- https://doi.org/10.1139/o61-122
Abstract
On each of 5 days, rabbits were given subcutaneously 75% of the single lethal dose of Pyramidon (aminopyrine), divided into three daily doses. The animals were killed on the 6th day and the degree of glutamic acid – oxaloacetic acid – transaminase activity of the liver and kidneys was examined. It could be established that activity in the liver increased by 41% and that of the kidneys by 87%. These values are correlated with the lesions which were previously noted in these organs. The increased seral activity as well as the ratio of activity of the organs of the treated and untreated animals is attributed to increased permeability and necrosis in hepatic and renal cells.Keywords
This publication has 2 references indexed in Scilit:
- EXPERIMENTAL EXAMINATION OF THE MECHANISM OF PYRAMIDON EFFECT: III. EFFECT OF HIGH PYRAMIDON DOSES ON THE GLUTAMIC ACID–OXALOACETIC ACID TRANSAMINASE ACTIVITY IN SERUMCanadian Journal of Biochemistry and Physiology, 1960
- SERUM GLUTAMIC OXALACETIC TRANSAMINASE ACTIVITY AS AN INDEX OF LIVER CELL INJURY: A PRELIMINARY REPORTAnnals of Internal Medicine, 1955