Blood Pressure Responses to Histamine Before and After Denervation of the Pressoreceptors

Publisher Website
Google Scholar
Abstract
Effects of graded doses of histamine upon blood pressure of the dog anesthetized with sodium pentobarbital were studied before and after denerva-tion of the pressoreceptors. Minimum blood pressure attained was higher at all dosage levels tested after denervation of the pressoreceptors. Analysis of covariance showed that the differences were not significant and could be related to elevation in control blood pressure resulting from the denervation procedure. Actual fall in blood pressure was significantly different only at the 2 highest dosage levels. This function was also related to the elevation of the control blood pressure. Duration of the depressor response for all but the 1.0 [mu]g/kg dose paralleled actual fall in blood pressure. The pressoreceptors were incapable of moderating blood pressure responses elicited by graded doses of histamine.

This publication has 3 references indexed in Scilit: