Transcript-level annotation of Affymetrix probesets improves the interpretation of gene expression data
Open Access
- 11 June 2007
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 8 (1) , 194
- https://doi.org/10.1186/1471-2105-8-194
Abstract
The wide use of Affymetrix microarray in broadened fields of biological research has made the probeset annotation an important issue. Standard Affymetrix probeset annotation is at gene level, i.e. a probeset is precisely linked to a gene, and probeset intensity is interpreted as gene expression. The increased knowledge that one gene may have multiple transcript variants clearly brings up the necessity of updating this gene-level annotation to a refined transcript-level.Keywords
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