Studies in Periodontal Disease

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Abstract
Blood studies of patients with periodontosis (primary periodontosis), periodontitis complex (secondary periodontosis) and advanced periodontitis simplex showed that deviations from normal ranges were present in a greater percentage of patients in each of these groups than in a control group free from periodontal disease. This was the case for vitamin C, glucose, globulin, albumin, calcium-ion, alkaline phosphatase, red blood count, white blood count and neutrophiles. The fact that more deviations were found in the groups with periodontal disease than in the control group suggests that one or more systemic conditions are associated with these diseases in many of the subjects studied. A record of the food intake over a period of one week indicated that a large percentage of the individuals in the control and periodontosis groups fell below the standards recommended by the Food and Nutrition Board of the National Research Council for calories, protein, Ca, P, Fe, thiamin, riboflavin and niacin. However, there was no fundamental difference between these groups. On the other hand with few exceptions, the intakes of vitamins A and C were adequate for both groups. Neutral 17-ketosteroid output in the urine was detd. to study adrenocortical activity. The mean output was somewhat greater in the control than in the periodontosis groups but the difference between the means of the 2 groups is not statistically significant. Physical examinations, including case histories did not reveal a common systemic condition responsible for periodontosis and periodontitis complex. A miscellaneous number of conditions were found in 58% of the cases. There was no difference between the control and periodontosis groups in the basal metabolic rate. The Kline Test was negative in all cases.

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