Aspirin resistance in secondary stroke prevention

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Abstract
Background – We investigated the platelet function in stroke patients treated with aspirin [acetylsalicylic acid (ASA)] for secondary stroke prevention during a follow‐up period of 1 year. Methods – In this prospective study 291 patients with first initiated aspirin therapy (300 mg/day) for secondary stroke prevention were included. Platelet aggregation measurements were performed 24 h, 3, 6, and 12 months after starting medication. Results – Twenty‐one of 291 patients (7.2%) were identified as primary ASA‐non‐responders (initial insufficient platelet inhibition) and 4.1% as secondary ASA‐non‐responders (insufficient platelet inhibition during follow‐up). There were no significant differences between ASA‐responders and ASA‐non‐responders concerning age, gender, risk factors, and stroke characteristics. Conclusion – Aspirin resistance in stroke patients is not uncommon. The clinical usefulness of routine platelet function tests needs to be proved by further trials.