Antifungal Clerodane Diterpenes from Macaranga monandra (L) Muell. et Arg. (Euphorbiaceae)
- 15 November 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (26) , 7607-7610
- https://doi.org/10.1021/jf034682w
Abstract
Hexane and ethyl acetate phases of the methanol extract of Macaranga monandra showed fungal growth inhibition of Colletotrichum acutatum, C. fragariae and C. gloeosporioides, Fusarium oxysporum, Botrytis cinerea, Phomopsis obscurans, and P. viticola. Bioassay-guided fractionation led to the isolation of two active clerodane-type diterpenes that were elucidated by spectroscopic methods (1D-, 2D-NMR, and MS) as kolavenic acid and 2-oxo-kolavenic acid. A 96-well microbioassay revealed that kolavenic acid and 2-oxo-kolavenic acid produced moderate growth inhibition in Phomopsis viticola and Botrytis cinerea. Keywords: Fungicide; antifungal activity; natural products; phytopathogenic fungi; microtiter assay; bioautographyKeywords
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