Hemoglobin Interaction: Modification of Solid Phase Composition in the Sickling Phenomenon
- 24 July 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 169 (3943) , 375-377
- https://doi.org/10.1126/science.169.3943.375
Abstract
Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin (Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C can participate in the filamentous fine structure characteristic of the sickling phenomenon. In contrast, fetal hemoglobin (Hb F) is nearly completely excluded.Keywords
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