Reactivity of Antibodies from Syphilis Patients to a Protein Array Representing theTreponema pallidumProteome

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Abstract
To identify antigens important in the human immune response to syphilis, the serum antibody reactivity of syphilitic patients was examined with 908 of the 1,039 proteins in the proteome ofTreponema pallidumsubsp.pallidumusing a protein array enzyme-linked immunosorbent assay. Thirty-four proteins exhibited significant reactivity when assayed with human sera from patients in the early latent stage of syphilis. A subset of antigens identified were further scrutinized for antibody reactivity at primary, secondary, and latent disease stages, and the results demonstrate that the humoral immune response to individualT. pallidumproteins develops at different rates during the time course of infection.