Guanosine 3′,5′-Monophosphate: A Central Nervous System Regulator of Analgesia
- 20 January 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4326) , 319-322
- https://doi.org/10.1126/science.202029
Abstract
The dibutyryl derivative of guanosine 3′,5′-monophosphate (cyclic GMP), administered centrally, totally abolishes response to noxious stimuli without depressing the central nervous system. Analgesic properties of the nucleotide are not reversed by naloxone. Microinjected intracerebrally into different sites, dibutyryl cyclic GMP does not mimic the action of morphine. Pharmacological effects of dibutyryl cyclic GMP suggest that endogenous cyclic GMP modulates an inhibitory pain pathway distinct from that on which morphine acts.This publication has 27 references indexed in Scilit:
- Central nervous system mechanisms of analgesiaPain, 1976
- Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental IllnessScience, 1976
- Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†Nature, 1976
- Identification of two related pentapeptides from the brain with potent opiate agonist activityNature, 1975
- Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the RatScience, 1974
- Effects of decapitation, ether and pentobarbital on guanosine 3′,5′-phosphate and adenosine 3′,5′-phosphate levels in rat tissuesBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Opiate Receptor: Demonstration in Nervous TissueScience, 1973
- Effects of amphetamine, chlorpromazine and reserpine on cyclic GMP and cyclic AMP levels in mouse cerebellumBiochemical and Biophysical Research Communications, 1972
- The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellumBiochemical and Biophysical Research Communications, 1970
- Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urineBiochemical and Biophysical Research Communications, 1963