Codon preference reflects mistranslational constraints: a proposal
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (9) , 4111-4120
- https://doi.org/10.1093/nar/16.9.4111
Abstract
Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA''s in Escherichia coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codon are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.This publication has 28 references indexed in Scilit:
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