Computersimulation von Wachstum und Produktbildung bei Saccharomyces cerevisiae

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Abstract
A mathematical model with three modifications was stated, which describes the diauxic growth of Saccharomyces cerevisiae on aerobic conditions in a glucose‐limited medium. The model was investigated by means of an analogcomputer. The first and simplest modification of the model is based on a well‐known growth model and includes an additional team for catabolic respression. This 1st model could be fitted without complications to the experimental data of a batch culture, which shows growth, consumption of glucose, and production of ethanol during a first log‐phase and growth and consumption of ethanol during a second log‐phase. Complementation with the terms necessary for continuous culture conditions gives the 2nd model and, therefore, the possibility to predict the properties of the corresponding continuous culture. The prediction agrees qualitatively with the experimental data. After consideration of additional factors as the inhibition of growth and ethanol production by ethanol a 3rd model allowed to fit the experimental data of a continuous culture.

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